Polyhexamethylene Biguanide Guide

It has a unique method of action: the polymer strands are incorporated into the bacterial cell wall, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[1] It has very low toxicity to higher organisms such as human cells, which have more complex and protective membranes. PAPB is a mixture of molecules of various sizes; different-sized molecules have a synergistic effect.

Some organisms such as Pseudomonas aeruginosa are able to develop resistance to this disinfectant.[2]...