Lactoperoxidase Guide

Lactoperoxidase is a peroxidase enzyme secreted from mammary, salivary, and other mucosal glands[2] that functions as a natural antibacterial agent.[3] Lactoperoxidase is a member of the heme peroxidase family of enzymes. In humans, lactoperoxidase is encoded by the LPO gene.[4][5]

Lactoperoxidase catalyzes the oxidation of a number of inorganic and organic substrates by hydrogen peroxide.[6] These substrates include bromide and iodide and therefore lactoperoxidase can be categorised as a haloperoxidase. Another important substrate is thiocyanate. The oxidized products produced through the action of this enzyme have potent bactericidal activities. Lactoperoxidase together with its inorganic ion substrates, hydrogen peroxide, and oxidized products is known as the lactoperoxidase system.[7]

The lactoperoxidase system plays an important role in the innate immune system by killing bacteria in milk and mucosal secretions hence augmentation of the lactoperoxidase system may have therapeutic applications. Furthermore, addition or augmentation of the lactoperoxidase system has potential applications in controlling bacteria in food and consumer health care products. The lactoperoxidase system does not attack DNA and is not mutagenic.[8] However, under certain conditions, the lactoperoxidase system may contribute to oxidative stress.[9] Furthermore, lactoperoxidase may contribute to the initiation of breast cancer, through its ability to oxidize estrogenic hormones producing free radical intermediates.[10]...